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lumacaftor/ivacaftor will reduce the level or result of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers decreases plasma concentration of abemaciclib and its metabolites.So that you know particularly how the solution need to gla